547: Meconium stained amniotic fluid as a protective factor against childhood dermatitis and skin rash in the offspring - A population based cohort analysis Academic Article uri icon


  • Objective The human microbiome plays a role in the pathogenesis of cutaneous diseases including atopic dermatitis. The microbiome's assembly is known to be influenced by mode of delivery, type of feeding and use of antibiotics. We investigated the possible impact of intrauterine extra-alimentary exposure to the infantile gut microbiome (meconium stained amniotic fluid-MSAF) recently found not to be sterile as previously thought, on the occurrence of dermatitis and skin rash in the offspring throughout childhood and adolescence. Study Design In this population-based cohort analysis all singleton deliveries occurring between 1991-2014 at a single tertiary medical center were included. The study population was divided into two study groups based on lack or presence of MSAF during delivery. Fetuses with congenital malformations were excluded. A Kaplan-Meier survival …

publication date

  • January 1, 2018