Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with f... Academic Article uri icon


  • Objective. Fetal death can lead to disseminated intravascular coagulation or fetal death syndrome. However, currently it is not clear what are the changes in the coagulation system in patients with a fetal death without the fetal death syndrome. This study was undertaken to determine:(1) whether fetal death in the absence of fetal death syndrome is associated with changes in hemostatic markers in maternal plasma and amniotic fluid; and (2) whether maternal hypertension or placental abruption are associated with further changes in the hemostatic profile of these patients. Methods. A cross-sectional study included the following:(1) determination of changes in markers of coagulation and platelet activation in patients with a normal pregnancy (n= 71) and patients with fetal demise (FD) without disseminated intravascular coagulation (n= 65);(2) determination of the amniotic fluid (AF) …

publication date

  • January 1, 2009