Visualization of membrane processes in living cells by surface-attached chromatic polymer patches Academic Article uri icon


  • 1092 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim DOI: 10.1002/anie. 200462393 Angew. Chem. Int. Ed. 2005, 44, 1092–1096 by membrane-active peptides.[4] Many of these membrane processes involve perturbations that affect the structural or dynamic properties of the phospholipid bilayers, or result in changes to the cell membrane or its morphology.[5] Numerous membrane studies employing model systems have been reported,[6] and varied techniques have been developed for imaging surface phenomena in living cells. Almost all the imaging methods are based on radioactive or fluorescent labels [7] or employ semiconductor quantum dots [8] that target specific molecules or biochemical pathways. However, microscopic imaging of localized plasma-membrane interactions and bilayer perturbations in living cells has not been achieved. Such information would greatly …

publication date

  • January 1, 2005