Reed-Sternberg cells in Hodgkin’s lymphoma present features of cellular senescence Academic Article uri icon

abstract

  • Hodgkin's Lymphoma (HL) is one of the most prevailing malignancies in young adults. Reed– Sternberg (RS) cells in HL have distinctive large cell morphology, are characteristic of the disease and their presence is essential for diagnosis. Enlarged cells are one of the hallmarks of senescence, but whether RS cells are senescent has not been previously investigated. Here we show that RS cells have characteristics of senescent cells; RS cells in HL biopsies specifically express the senescence markers and cell cycle inhibitors p21 Cip1 and p16 INK4a and are negative for the proliferation marker Ki-67, suggesting that these cells have ceased to proliferate. Moreover, the RS-like cells in HL lines, stained specifically for senescence-associated β-galactosidase (SA-β-gal). Oxidative stress promoted senescence in these cells as demonstrated by their staining for p21 Cip1, p16 INK4a, p53 …

publication date

  • November 1, 2016