48: A role for CXCL13 in the host response to intra-amniotic infection Academic Article uri icon


  • Objective CXCL13 is a novel chemokine produced by mature and recently recruited macrophages to sites of inflammation, which has anti-microbial and anti-angiogenic properties. A role for CXCL13 has been proposed in placental malaria. However, little is known about this chemokine in normal pregnancy, as well as in those associated with bacterial infection. The purpose of this study was to determine whether CXCL13 is present in amniotic fluid (AF) and if its concentration changes with intra-amniotic infection/inflammation (IAI). Study design A cross-sectional study was performed including patients in the following groups: 1) midtrimester (n= 65); 2) term not in labor (n= 22); 3) term in labor (n= 47); 4) preterm labor (PTL) with term delivery (n= 55); and 5) PTL leading to preterm delivery with (n= 42) and without (n= 68) IAI. CXCL13 concentrations were determined by ELISA. Non …

publication date

  • December 1, 2007