OP14. 05: A link between an anti-angiogenic state in the first trimester and abnormal uterine artery Doppler in the midtrimester Academic Article uri icon


  • Objective The aim of this study was to examine if maternal plasma concentrations of placental growth factor (PlGF), soluble vascular endothelial growth factor receptor− 1 (sVEGFR-1) and soluble endoglin (sEng) in the first trimester (1T) were associated with the subsequent development of abnormal uterine artery Doppler velocimetry (UTDV) in the second trimester (2T). Study design This study is based on a cohort study design to examine the predictive value of PlGF, sEng and sVEGFR-1 plasma concentrations in the identification of patients destined to develop PE. Only patients that had samples obtained between 8–13 weeks and subsequently had UTDV between 20–25 weeks were included (n= 1,316). Results 1) Women destined to have abnormal UTDV in the 2T had a lower median 1T plasma PlGF concentration than those with normal UTDV; 2) 1T plasma PlGF …

publication date

  • January 1, 2009