α1-Antitrypsin modifies general natural killer cell interactions with dendritic cells and specific interactions with islet β-cells in favour of protection from autoimmune di... Academic Article uri icon

abstract

  • Summary The autoimmune destruction of pancreatic β-cells is the hallmark of type 1 diabetes (T1D). Failure of anti-CD3 antibodies to provide long-lasting reversal of T1D and the expression of a natural killer (NK) cell ligand on β-cells suggest that NK cells play a role in disease pathogenesis. Indeed, killing of β-cells by NK cells has been shown to occur, mediated by activation of the NK cell activating receptor, NKp46. α1-Antitrypsin (AAT), an anti-inflammatory and immunomodulatory glycoprotein, protects β-cells from injurious …

publication date

  • March 1, 2015