The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria. Academic Article uri icon

abstract

  • Background: The natural history of the progression from acute spontaneous urticaria (ASU) to chronic spontaneous urticaria (CSU), CSU remains poorly understood. Objective: To identify clinical and laboratory patient attributes that may be predictive of ASU progression to CSU. Methods: We prospectively studied consecutive adult patients (age ≥ 18 years) with a diagnosis of urticaria of Results: Of 114 patients with acute urticaria and without identifiable causes, 73 patients (64%) were included in the ASU group, 41 patients in the CSU group (36%), and 44 healthy subjects in the control group. At baseline, 26 patients in the CSU group (63.4%) had a positive ASST result, whereas only 17 patients with a positive ASST result (23.3%) were revealed in the ASU group (p 3) and more anti-thyroid peroxidase antibodies (18 [41.8%]) than those with the negative baseline ASST result (mean [standard deviation], 0.13 ± 0.09 cell/mm³, p Conclusion: The patients with ASU who progressed toward CSU were characterized by a positive ASST result, thyroid autoimmunity, and profound basopenia at baseline.

publication date

  • January 1, 2016