Ultrasound-induced transcutaneous transport for drug delivery and diagnostics Academic Article uri icon


  • In spite of major research and development efforts in transdermal systems and the many advantages of the transdermal route, impermeability of the human skin is still a major problem that limits the usefulness of the transdermal drug delivery approach. Application of ultrasound induces temporary structural changes in the skin resulting in enhanced transdermal transport of molecules (sonophoresis). Experimental findings suggest that among all the ultrasound‐related phenomena evaluated, cavitation plays the dominant role in sonophoresis, suggesting that application of low‐frequency ultrasound should enhance transdermal transport more effectively. It was found that at the low ultrasound frequencies high molecular weight molecules including insulin, interferon, and erythropoietin can be transported through the skin. Recently it was shown that the enhanced skin permeability …

publication date

  • May 1, 1998