Inositol treatment in psychiatry. Academic Article uri icon


  • Abstract Describes the use of inositol, a naturally occurring isomer of glucose, a key intermediate of the phosphatidyl-inositol (PI) cycle, and a 2nd messenger system used by several neuroreceptors, for psychiatric treatment. It has been hypothesized that lithium might be effective in treating mania by reducing inositol levels in the brain. Animal and clinical studies have shown that orally administered inositol reverses behavioral effects of lithium in animals and its side effects in humans. Inositol levels are low in depression, and studies show that inositol was often effective as the sole therapy for depression. It was also as effective as imipramine in the treatment of panic-disorders. However, it has not been useful in treating other psychiatric disorders, such as, schizophrenia. Though it has been found to be safe and non-toxic, further studies are needed to expand on and replicate these …

publication date

  • January 1, 1995