Too Much of a Good Thing May Not Be Wonderful: GluR1 Phosphorylation and the Consequences of Early-Life Seizures Academic Article uri icon

abstract

  • Excessive GluR1 Phosphorylation Following Neonatal Seizures were substituted for serines at the S831 and S845 sites, resulting in GluR1 subunits that cannot be phosphorylated. The animals are termed GluR1–double-phosphomutants (DPM). GluR1-DPM mice have defective long-term synaptic plasticity in vitro, and reduced learning and retention abilities on several behavioral tasks (9, 10). The first step for Rakhade et al. in exploring seizure effects in mice was to determine the developmental expression profile of several …

publication date

  • January 1, 2013