Dynamics of Severe and Non-Severe Invasive Pneumococcal Disease in Young Children in Israel Following PCV7/PCV13 Introduction. Academic Article uri icon


  • The introduction of the pneumococcal conjugated vaccines (PCVs) resulted in a substantial reduction of invasive pneumococcal disease (IPD) rates. However, impact on non-severe IPD (mostly occult bacteremia) has not yet been fully elucidated. We assessed severe and non-severe IPD (SIPD and NSIPD, respectively) rate dynamics in children< 5 years in Israel before and after PCV7/PCV13 implementation. A prospective, population-based, nationwide surveillance. All IPD episodes recorded from 1999 through 2015, were included. NSIPD was defined as IPD episodes without meningitis, pneumonia or mastoiditis in a child with a favorable outcome (not-hospitalized or hospitalized in a non-intensive care unit< 5 days, without mortality). Three sub-periods were defined: pre-PCV (1999-2008), PCV7 (2010- 2011) and PCV13 (2013-2015). Incidence rate ratios (IRRs) were calculated. Overall …

publication date

  • January 1, 2018