Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis Academic Article uri icon

abstract

  • Abstract The impact of inherited genetic variation on gene expression in humans is well- established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes (cis-eQTLs). More research is needed to identify effects of genetic variation on distant genes (trans-eQTLs) and understand their biological mechanisms. One common trans-eQTLs mechanism is “mediation” by a local (cis) transcript. Thus, mediation analysis can be applied to genome-wide SNP and expression data in order to identify …

authors

publication date

  • November 1, 2017