OP11. 03: Can the severity of the maternal anti-angiogenic state of pre-eclampsia be detected by Doppler velocimetry? Academic Article uri icon


  • Objectives Pre-eclampsia (PE) is thought to be causally related to an “anti-angiogenic state” characterized by increased concentrations of soluble endoglin (Nature Medicine 2006; 12: 642–9) and soluble VEGFR-1 (NEJM 2004; 350: 672–83). This “anti-angiogenic state” may be reflected by changes in the impendence to flow in the maternal and fetal circulations. The objective of this study was to examine the relationship between abnormalities in uterine (UT) and/or umbilical artery (UA) Doppler velocimetry and maternal plasma concentration of the powerful anti-angiogenic factor, endoglin, in patients with PE. Study Design A cross- sectional study was conducted in normal pregnant women (n= 135) and patients with PE (n= 69). Patients with PE were sub-classified into four groups according to the results of UT and UA artery Doppler velocimetry. Plasma concentrations of soluble endoglin (sEng) were …

publication date

  • January 1, 2008