Rejuvenation of Aged Hematopoietic Stem Cells Academic Article uri icon

abstract

  • Due to advances in medicine and public health programs we are living longer than ever. Aging affects many biological processes, among them is the immune system ability to respond to vaccinations and fight infections, which declines as we age [1, 2]. Strikingly, the aged population is extremely susceptible to influenza and 80-90% of influenza related mortalities occurs in patients of 65 years old or older [3]. Elderly may also suffers from autoimmunity [4], another indication for irregularities in the aged immune response. Sub- clinical anemia and increased frequencies of specific leukemia types further highlight the health impact of the hematopoietic system [2]. It is clear that there is a need to improve and rejuvenate an individual's aged immune response but is it feasible and if so how? Hematopoietic stem cells (HSCs) are the continuous source of the various lymphocytes …

publication date

  • January 1, 2016