The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus Academic Article uri icon

abstract

  • Highly pathogenic avian influenza viruses pose a continuing global threat. Current vaccines will not protect against newly evolved pandemic viruses. The creation of 'universal'vaccines has been unsuccessful because the immunological mechanisms that promote heterosubtypic immunity are incompletely defined. We found here that rapamycin, an immunosuppressive drug that inhibits the kinase mTOR, promoted cross-strain protection against lethal infection with influenza virus of various subtypes when administered during …

publication date

  • January 1, 2013