Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity. Short note Academic Article uri icon

abstract

  • Summary Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.

publication date

  • February 1, 1988