Prevention of relapse in schizophrenia Academic Article uri icon


  • In 1973, the Psychopharmacology Research Branch of the National Institute of Mental Health initiated a multi-clinic collaborative study. At that time, results of the prospective trials were not available. Therefore, a major objective of the study was to evaluate the effectiveness of the long-acting injected neuroleptic fluphenazine deca¬ noate in controlling psychopathology and in averting relapse in patients diagnosed as schizophrenic when acute¬ ly ill and subsequently treated in the community. An important feature of the study was the use of a potentially efficient and cost-effective model of treatment delivery involving long-acting neuroleptics. A treatment team at each institution (psychiatrist, registered nurse, and research assistant) provided both continued medica¬ tion and general support and care. The nurse was the initial contact for each patient, who was seen once every three …

publication date

  • January 1, 1980