.Short-term lithium treatment does not reduce human CSF inositol levels Academic Article uri icon


  • Seven schizophrenic male patients (aged 32–55 yrs), were treated with Li (1,200 mg per day) for 3 days. Lumbar puncture was performed before Li treatment started and on the 4th day. Two other male patients (aged 39 and 42 yrs) with schizophrenia were treated with Li for 7 days, and lumbar puncture was performed on the 8th day. No reduction in CSF inositol levels was detected, although Li treatment has been found to reduce inositol levels in rat brain. The results may be due to the short time period, the low dosage of Li, or the fact that brain inositol levels are much higher than are CSF levels and may not be reflected in CSF levels. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

publication date

  • November 1, 1993