Osteoporosis and schizophrenia. Academic Article uri icon


  • TO THE EDITOR: In the August issue of the Journal, Charles P. O'Brien, MD, Ph. D.(1) stated the following about modafinil, a drug that he reported may decrease cocaine use in some cocaine users:“The medication has not been reported to produce euphoria, and there has been no indication of excessive use or abuse in clinical trials”(p. 1428). As the scientific basis for his comment, the author referenced his own group's work (2). The author's statement does not appear to be supported by his referenced work, nor is it supported by information widely available in the 2004 edition of the Physicians' Desk Reference (PDR). The referenced article, for example, may demonstrate that modafinil can, in some cases, blunt cocaine euphoria. However, it does not say anything about modafinil's intrinsic ability to produce euphoria (or not). Separately, the 2004 PDR raises specific concerns about …

publication date

  • January 1, 2006