The use of recombinant factor VIIa in severe postpartum hemorrhage Academic Article uri icon


  • Severe postpartum hemorrhage (SPPH) from uterine bleeding and profuse hemorrhage of pelvic origin may lead to hemorrhagic shock, consumption coagulopathy and disseminated intravascular coagulopathy (DIC). These are life-threatening situations that require fast and efficient treatment, including contraction of the uterus, removal of the placenta, correction of coagulopathy, ligation of uterine or internal iliac arteries, hysterectomy or arterial embolization (1). Recombinant activated factorVII (rFVIIa) has been shown to correct severe coagulopathy and control life-threatening bleeding (2,3). The use of rFVIIa in obstetrics is also encouraging (4,5).

publication date

  • January 1, 2004