The effect of inositol on cognitive processes and mood states in normal volunteers Academic Article uri icon


  • Inositol is a simple isomer of glucose and is present in a normal diet in quantities of about 1 g/day. Recently inositol has become of critical interest in brain neurochemistry and psychopharmacology because of its role in the phosphatidylinositol (PI) cycle. The PI cycle represents a key signal transduction system for many neurotransmitters in the human brain including acetylcholine, noradrenaline, histamine, serotonin,/~-endorphin and vasopressin. These neurotransmitters have been shown to be involved in cognitive processes and mood states. The following study examined the effect of inositol 12 g, a dose shown to penetrate human blood brain barrier (Levine et al., 1993b), on cognitive processes and mood of 11 healthy volunteers. There were three males and eight females, mean age 42.0 _+ 9 (23-56), mean years of education 17_+ 3 (13-24). Five subjects were given inositol first and …

publication date

  • January 1, 1994