S156. Cognitive Effects of Deep Transcranial Magnetic Stimulation for Late-Life Depression Academic Article uri icon


  • Background Late-life depression (LLD) is a growing global public health issue due to demographic changes. LLD is associated with cognitive functioning impairment. Deep repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for depression in younger adults associated with improved cognition; however, the impact of deep rTMS on cognition in LLD has not been explored. Methods We randomized adults 60-85 years (n= 52) with major depressive disorder (MDD) to sham or active deep rTMS (H1 coil, 6012 pulses, 18Hz, 120% resting motor threshold) delivered over the dorsolateral and ventrolateral prefrontal cortex five days per week over four weeks. Cognitive outcomes were the Repeatable Battery for the Assessment of the Neuropsychological Status (RBANS) and two Delis-Kaplan Executive Function System (DKEFS) subscales: Color Word …

publication date

  • January 1, 2018