Antithrombotic medication use and dementia incidence among people with mild cognitive impairment and atrial fibrillation Academic Article uri icon


  • Background Atrial fibrillation (AF) is an established risk factor for stroke and transient ischemic attacks (TIA), which in turn elevate dementia risk. However, AF also may be an independent risk factor for dementia. In the absence of an established cause for higher dementia incidence among patients diagnosed with AF, the role of antithrombotic medications, including both anticoagulants and antiplatelets, is investigated. Methods Study participants included patients with mild cognitive impairment enrolled at a National Institutes on Aging Alzheimer's Disease Center (ADC) who were aged 50+ years and reported AF at any ADC visit prior to dementia diagnosis. Patients with documented stroke or TIA were excluded. Our exposure was time-varying self-reported antithrombotic medication use, assessed at every ADC visit. We modeled dementia incidence using logistic regression …

publication date

  • July 1, 2013