S. 09.04 New treatments for compulsive disorders Academic Article uri icon


  • Animal studies have previously demonstrated that glutamate homeostasis in the striatum is disrupted following cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expression and reduced glutamate turnover. The goal of this study was to use imaging of the human brain to investigate alterations in the glutamate signaling in cocaine abuse. Positron Emission tomography (PET) imaging with the radiotracer [11C] ABP688 was used to image mGluR5 binding and magnetic resonance spectroscopy (MRS) was used to measure glutamate-glutamine levels in the striatum of subjects with a substance use disorder (SUD) to cocaine compared to healthy controls. Following the scans, the cocaine abusing volunteers performed cocaine self-administration sessions in order to investigate the correlation between cocaine seeking behavior and mGluR5 receptor …

publication date

  • January 1, 2014