731: Maternal smoking during pregnancy and long-term gastrointestinal morbidity in the offspring: Results from a single-center population-based cohort study Academic Article uri icon


  • Objective Maternal smoking in pregnancy is a known risk factor for several birth defects, and long-term behavioral and cognitive problems in the offspring. Our objective was to investigate whether maternal smoking increases the risk for long-term gastrointestinal (GI) morbidity in the offspring. Study Design A population-based cohort study of deliveries in 1991-2014 was conducted, comparing incidence of pediatric GI related hospitalizations in offspring of mothers self-reported to have been smoking during pregnancy vs. mothers who did not. Congenital malformations and multiple gestations were excluded. Follow-up time was calculated from birth to either an event, death, age 18, or to the end of the study period (censored). A Kaplan-Meier survival analysis was used to estimate cumulative incidence of GI morbidity, and a Cox proportional hazards model was used to estimate the adjusted …

publication date

  • January 1, 2018