236: Maternal hypothyroidism during pregnancy is not a risk factor for long-term morbidity of the offspring Academic Article uri icon


  • Objective To investigate whether in-utero exposure to hypothyroidism increases the risk of long-term pediatric morbidity of the offspring. Study Design A retrospective population-based cohort study compared long-term pediatric morbidity between singletons exposed and unexposed to maternal hypothyroidism. Deliveries occurred in a regional tertiary medical center between the years 1991-2014. Congenital malformations were excluded from the study. A multivariate generalized estimating equation (GEE) logistic regression model analysis was used to control for confounders and for maternal clusters. Results During the study period 255352 deliveries met the inclusion criteria; 1.0% of deliveries were diagnosed with hypothyroidism (n= 2613). During the follow-up period, children exposed to hypothyroidism did not have a significantly higher rate of long-term (up to the age of 18 …

publication date

  • January 1, 2016