Hypothermia-induced neuroprotection in rats: evidence of a blood glutamate scavenging mechanism: 7AP2-1 Academic Article uri icon


  • Materials and Methods: Rats were anesthetized with Isoflurane and their core temperate was kept at either 36-37 C, 33-36 C, 30-32 C, 12-22 C, or not maintained artificially for 6 consequent hours. There were 12 rats in each group for a total of 60 rats. Blood samples were subsequently drawn at 0, 3, 6, 12, 24 and 48 hours for the determination of blood glutamate, GOT and GPT. Results and Discussion: Mild and moderate hypothermia led to reduced blood glutamate levels (p< 0.001). A strong correlation between body temperature and blood glutamate levels was demonstrated (p< 0.001). Severe hypothermia was associated with significant elevations in blood glutamate levels (p< 0.001). Hypothermia, irrespective of the degree, led to elevations in GOT in plasma (p< 0.001). Conclusions: Mild and moderate hypothermia led to a reduction in blood glutamate levels in rats, while …

publication date

  • June 1, 2012