A High-Resolution Structure that Provides Insight into Coiled-Coil Thiodepsipeptide Dynamic Chemistry Academic Article uri icon

abstract

  • Chemical synthesis and cell-based expression methods can afford incorporation of non- natural entities into proteins. New structures are obtained, and new functions gained, by attachment of amino acids with non-native side-chains,[1, 2] modified backbones such as b- and g-amino acids,[3–5] or peptide bond analogues such as peptoids, esters, and thioesters.[6–9] Backbone modification with longer and flexible amino acids allows expansion of the conformational space occupied by proteins, while introduction of ester …

publication date

  • September 16, 2013