Refined genetic mapping of X-linked thoracoabdominal syndrome Academic Article uri icon

abstract

  • The gene for thoracoabdominal syndrome (TAS) has been previously mapped to human chromosome Xq25-26. We have refined the localization of the TAS gene to Xq27 using new polymorphic markers, with no recombination observed with markers DXS1232 and DXS984. Based on cytogenetic and phenotypic observations, it is conceivable that the region Xq24-q27 contains a cluster of developmental genes that operate in a concerted fashion. 15 refs., 1 tab.

publication date

  • January 1, 1996