The locomotor and behavioral patterns following both a singleinjection and double-injection rat model of subarachnoid hemorrhage: 7AP1-1 Academic Article uri icon


  • Materials and Methods: SAH was induced in 48 rats by 0.3 ml injection of autologous arterial blood into the cisterna magnum (single-injection model). Post-SAH vasospasm was induced in 24 of these rats by a second injection of blood into the cisterna magnum after 24 hours (double-injection model). 0.3 ml of saline was injected into the cisterna magnum of 24 additional rats (sham group). Neurological performance was measured at 24, 48 hours, 1, 2 and 3 weeks following SAH. 3 weeks after SAH, four behavioral tests were performed for the duration of 6 consequent days: open field test, sucrose preference test, elevated plus maze test and swimming test. Results and Discussion: There was impaired neurological performance by 24 hours following SAH (P< 0.0001). For the open field test, the double- injection model was associated with less total travel distance (P< 0.005), reduced mean …

publication date

  • June 1, 2013