Nucleoid Segregation Dynamics and its Variability in Dividing and Filamentous E. Coli Academic Article uri icon

abstract

  • 1628-Pos Board B537 Calcium Channel Blockers Effect on Motility : a Novel Target in Biomedical Research Negar Motayagheni. WFIRM, Winston Salem, NC, USA. Introduction Each year in the United States many people become infected with bacteria that are resistant to antibiotics and many people die as a result of infection. They grow on medical devices such as heart valves, and catheters also take root within wounds and implants and cost the health care system millions per year. Calcium homeostasis is a key factor for multiple functions including motili- ty,aggregation and biofilm formation in bacteria. We report here that swimming motility and biofilm formation in pathogenic Escherichia coli and Proteus mir- abilis is inhibited by verapamil, a calcium channel blocker. The core concep- tion for this study is that Calcium Channel Blockers will prevent bacterial motility and biofilm formation. Methods We tested the effect of verapamil (3 and 6 mM), on …

publication date

  • January 1, 2018