Chronic mild stress induces depressive behaviors in adult but not young rats: potential role for AMPA receptors and brain-derived neurotrophic (BDNF) factor. Conference Paper uri icon

abstract

  • Text Exposure to chronic mild stress (CMS) is known to induce anhedonia in adult animals and is associated with the development of depressive neurosis (dysthymia) in humans. However, the behavioral effects of CMS in young animals have not been characterized and little is known about the long-term neurochemical effects of CMS in either young or adult animals. In this study we compared the effect of 4 weeks of chronic mild environmental stressors in young (30 days) versus adult male rats on various behaviors. We measured spontaneous locomotor activity in the home cage, explorative behavior in an open field, the forced swim test, preference for sweet solutions and the sexual behavior. We have also measured expression of AMPA receptors and BDNF within specific reward-related brain regions of the various groups. Here, we found that only in adult but not in young animals …

publication date

  • January 1, 2005