Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-κB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain Academic Article uri icon


  • Abstract Protein kinase C-θ (PKCθ) is a Ca 2+-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and is thought to play an important role in T cell receptor-induced activation. To gain a better understanding of the function and regulation of PKCθ, we have employed the yeast two-hybrid system to identify PKCθ-interacting proteins. We report the isolation and characterization of a cDNA encoding a novel 335-amino acid (37.5-kDa) PKCθ-interacting protein termed PICOT (for P KC-i nteracting c ousin oft …

publication date

  • January 21, 2000