Tiapride as Treatment for Certain Patients with Idiopathic Torsion Dystonia Academic Article uri icon

abstract

  • Idiopathic torsion dystonia (ITD) is a disease of the basal ganglia characterized by twisting, turning and writhing movements of any or all somatic voluntary muscles. The movements sometimes resemble athetosis but are slower, stronger and sustained in character. The pathological changes are not clearly known. No consistent biochemical deficit has as yet been found and the biochemical characteristics of ITD remain poorly understood [1]. Eldridge [2] postulated that two types of ITD exist. In one type, allegedly limited to Jews of European (Ashkenazi) origin, limbs are affected before axial muscles, onset occurs early in life and the inheritance pattern is recessive. The other type is seen in non-Jews, affects axial muscles primarily, starts later in life and is inherited as a dominant trait. Occasional occurrence, however, of the recessive trait has been reported among non-Jews [2]. As no drugs are known to cure ITD, the treatment is directed to symptomatic …

publication date

  • January 1, 1991