202: Granulocyte chemotactic protein-2 (CXCL6): A novel chemokine involved in the innate immune response of the amniotic cavity Academic Article uri icon


  • Objective Granulocyte chemotactic protein-2 (CXCL6) is a potent neutrophil chemoattractant and activator. It functions as a pro-inflammatory and angiogenesis-promoting chemokine. CXCL6 is unique in that it acts as a ligand to both CXCR1 and CXCR2 receptors (similar to IL-8). The purpose of this study was to determine if: 1) CXCL6 is present in the amniotic cavity; and 2) CXCL6 concentrations in amniotic fluid (AF) change with labor (preterm and term) or intra-amniotic infection/inflammation (IAI). Study design A cross sectional study was conducted including the following groups: 1) mid-trimester (n= 65); 2) term not in labor (n= 20); 3) term in labor (n= 44); 4) preterm labor (PTL) without IAI who delivered preterm (n= 47); 5) PTL with IAI (n= 62); and 6) patients with PTL who delivered at term (n= 57). AF CXCL6 concentrations were determined by ELISA. Non-parametric statistics were used …

publication date

  • December 1, 2007