Preeclampsia and SCD30 Academic Article uri icon

abstract

  • Objective Preeclampsia (PE) is characterized by exaggerated intravascular inflammation and a predominantly Th1-biased immune response. There is controversy about the Th2 response in PE. CD30, a member of the tumor necrosis factor receptor superfamily, is preferentially expressed in vitro and in vivo by activated T cells producing Th2-type cytokines. Its soluble form (sCD30) is considered a marker for a Th2 immune response. The objective of this study was to determine the maternal serum concentration of sCD30 in patients with PE. Study design This cross-sectional study included patients in the following groups: 1) non-pregnant women (n= 20); 2) normal pregnancy (n= 61); 3) PE (n= 92); and 4) patients who delivered a small for gestational age (SGA) neonate (n= 41). Maternal serum concentration of sCD30 was measured by specific and sensitive enzyme-linked …

publication date

  • December 1, 2006