Rotavirus. Academic Article uri icon

abstract

  • Rotaviruses (RVs) form the genus Rotavirus of the Reoviridae family of viruses. The RV genome consists of 11 segments of double-stranded RNA and is enclosed within 3 concentric protein layers (capsids). Viral protein (VP) 2 represents the core or inner capsid, whereas VP6 constitutes the middle capsid, determines serogroup antigen specificity (A–G), and is the most immunogenic protein in RV infection. Group A, B, and C RVs all have been identified in humans, with group A RV responsible for the majority of disease (1, 2). Group A RVs are differentiated by serotype, which is determined on the basis of the antigens expressed on the outer viral capsid, VP7 (a glycoprotein, which defines the G-type antigens) or VP4 (a protease-cleaved protein, which defines the P-type antigens)(1, 3). Analogous to the classification of influenza viruses, RV classification is a binary system that includes …

publication date

  • May 1, 2008