A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells Academic Article uri icon

abstract

  • The transcription factor Foxp3 participates dominantly in the specification and function of Foxp3+ CD4+ regulatory T cells (T reg cells) but is neither strictly necessary nor sufficient to determine the characteristic T reg cell signature. Here we used computational network inference and experimental testing to assess the contribution of other transcription factors to this. Enforced expression of Helios or Xbp1 elicited distinct signatures, but Eos, IRF4, Satb1, Lef1 and GATA-1 elicited exactly the same outcome, acting in synergy with Foxp3 to …

publication date

  • January 1, 2012