Notch activation enhances IFNγ secretion by human peripheral blood and decidual NK cells Academic Article uri icon


  • NK cells specialize in killing tumor cells and virally infected cells and also possess non- cytotoxic functions, which include secretion of a variety of cytokines and growth factors. Their activity is mediated by a vast repertoire of inhibitory and activating NK receptors. Recently, it was demonstrated that ligation of the Notch receptor plays a significant role not only in T cell development but also in human T cell and mouse NK cell activation. However, the involvement of Notch triggering in human NK cell activity has not yet been determined …

publication date

  • January 31, 2010