Changes in interleukin levels in CSF and serum of schizophrenic patients Academic Article uri icon


  • Several recent studies have yielded support for a 3-factor model of schizophrenia, including a negative symptom"'poverty" syndrome, a" disorganization" syndrome, and a"'reality distortion syndrome," postulated by some to be related to abnormalities of prefrontal and/or medial temporal cortical function. The majority of factor analytic studies have been limited by relatively small, and predominantly male, subject samples. In Study i we examined the generalizability of the 3-factor model to both males and females in a sample of 159 inpatients (90 males and 69 females) with DSM-II1-R (SCID-diagnosed) schizophrenia. A principal components analysis conducted on the positive and negative symptom scales of the SAPS and the SANS yielded a 3-factor solution which closely approximated the 3-factor solutions reported by previous investigators. Independent factor analyses conducted on …

publication date

  • January 1, 1995