Complex clinical and microbiological effects on Legionnaires’ disease outcome; A retrospective cohort study Academic Article uri icon

abstract

  • Legionnaires' disease (LD) is associated with high mortality rates and poses a diagnostic and therapeutic challenge. Use of the rapid urinary antigen test (UAT) has been linked to improved outcome. We examined the association between the method of diagnosis (UAT or culture) and various clinical and microbiological characteristics and outcome of LD. Consecutive patients with pneumonia and confirmation of Legionella infection by a positive UAT and/or a positive culture admitted between the years 2006–2012 to a university hospital were retrospectively studied. Isolated L. pneumophila strains were subject to serogrouping, immunological subtyping and sequence-based typing. Variables associated with 30-day all- cause mortality were analyzed using logistic regression as well as cox regression. Seventy- two patients were eligible for mortality analyses (LD study group), of whom 15.5% have …

publication date

  • February 10, 2016