- To evaluate the effect of non-obstetric invasive procedure during pregnancy on perinatal outcome. The present retrospective study investigated perinatal outcome in women that underwent an invasive procedure during one of their pregnancies (n = 61); perinatal outcome was compared to other pregnancies (without an invasive procedure) of the same patients (n = 122). Women with a non-obstetric invasive procedure during pregnancy delivered earlier than those in the comparison group (38.5 vs. 40.0 weeks; p = 0.01) and had a significantly higher rate of cesarean sections (18 vs. 5 cases; p < 0.01). In addition, birth weight was significantly lower in patients undergoing invasive procedures during pregnancy (2908.65 vs. 3185.84 gr; p = 0.02). The absolute rate of prematurity (<37 weeks) was non-significantly higher in the study group (18.3 vs. 10.0 %; p = 0.28). Non-obstetric invasive procedures are associated with an increased rate of cesarean sections and lower birth weight. Nevertheless, no significant differences in early perinatal outcome were found in comparison to other pregnancies of the same patients. More studies are needed to evaluate the outcome following specific procedures.