The human PICOT protein possesses a thioredoxin-like homology domain and a tandem repeat of a novel domain which is highly conserved during evolution Academic Article uri icon


  • The critical role of PKC0 in T cell activation has already been established, but its mode of regulation during the activation response has not been fully defined. To identify PKC8- binding parmers, which may function as putative regulators of the enzyme, we performed a yeast two hybrid screen of a human T cell cDNA library, and found that a new protein, termed PICOT tGenBank accession no. AAF288441 specifically interacts with PKC6 The human PICOT protein includes 335 amino acids and possesses an N-terminal …

publication date

  • January 1, 2001