- In the RPL field, some aspects including evaluation, diagnosis, and treatment have been controversial for many years. Research lacks randomized clinical trials as well as multicenter studies that will help enlarge the number of women inspected in each trial. In order to provide evidence-based recommendations to the couples who deal with RPL, research should take a more creative direction when investigating etiologies and treatments. Here, we focus on the most advanced research in RPL, including multifactorial approach towards RPL, heparin’s role not as anticoagulant, immune systems’ role, and new discoveries on different molecules. Although some of these articles are only the beginning, exposing the tip of the iceberg, and it might take a long period of time before they achieve their goals.