Conjugate pneumococcal vaccine and antibiotic-resistant Streptococcus pneumoniae : herd immunity and reduction of otitis morbidity Academic Article uri icon


  • Respiratory infections are the most common cause of morbidity in childhood. Bacterial respiratory infections can occur either as primary infections or as a secondary complication of viral infections. Streptococcus pneumoniae is one of the most important bacterial pathogens in respiratory tract infections. Together with untypable Haemophilus influenzae, it is one of the two most common causes of acute otitis media (AOM). In addition it is the most frequent cause of bacterial community-acquired pneumonia and one of the leading organisms causing sinusitis, sepsis and meningitis. The main reservoir of S. pneumoniae is the nasopharynx. From there the organism can:(1) enter the bloodstream to cause invasive infections such as sepsis, meningitis and infections in remote foci such as joints, bones and soft tissues;(2) spread to adjacent mucosal tissues to cause mucosal infections such as …

publication date

  • May 1, 2000