GSK-3ß in cerebrospinal fluid of schizophrenia patients Academic Article uri icon

abstract

  • Summary. Cerebrospinal fluid contains proteins and metabolites of brain origin and was extensively studied in psychiatry in the 1970's with few definitive results. We have recently found 40% reduced protein levels of GSK-3β in schizophrenia in postmortem prefrontal cortex, but our attempt to develop a diagnostic marker using peripheral lymphocyte GSK-3β was not successful. In this study we aimed to find whether the reduction in brain GSK-3β is reflected in CSF of schizophrenia patients. We report a significant reduction in CSF GSK …

publication date

  • August 1, 2004