HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection Academic Article uri icon

abstract

  • Abstract Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term “targeting efficiency,” and that this preference may provide improved clearance of infection in several viral systems. To test this hypothesis, T-cell responses to A/H1N1 (2009) were measured from peripheral blood mononuclear cells obtained from a household cohort study performed during the 2009– 2010 influenza season. We found that HLA targeting efficiency scores significantly …

publication date

  • August 13, 2013