Epidemiology & outcome in CKD 5D (1) Academic Article uri icon

abstract

  • Abstract INTRODUCTION AND AIMS: Higher residential altitude has been associated with greater erythropoietin response and longer survival in ESRD patients. It has been hypothesized that persistent activation of hypoxia-inducible factors (HIF) at higher altitude may explain these associations. Animal models have shown that inactivation of prolyl- hydroxylases-regulators of HIF-suppresses mammary gland proliferation in vitro, with similar findings in lung, brain, and hematopoietic cancer lines. Thus, HIF activation may also affect cancer incidence in vivo. No studies have evaluated the association between altitude and cancer incidence. METHODS: We studied incident ESRD patients (1996-2006) who had no diagnosis of cancer prior to initiation of chronic dialysis. We required 2 medical claims with a cancer diagnosis (except for non-melanoma skin cancer) to define incident cancer. We …

authors

publication date

  • January 1, 2011