Chemical-retroviral cooperative carcinogenesis and its molecular basis in NIH/3T3 cells Academic Article uri icon


  • Abstract We demonstrate in this study that infection with Moloney murine leukemia virus (M- MLV) and exposure to 3-methyl-cholanthrene (3-MC) can cooperate to transform NIH/3T3 mouse fibroblasts. M-MLV seems to stimulate the expression of c-myc and of a certain major histocompatibility complex (MHC) class I gene. Yet M-MLV infection by itself is insufficient to transform these cells. However, exposure of the ingected cells to 3-MC resulted in a rapid cell transformation with concomitant enhancement of c-Ha-ras and H-2K class I MHC …

publication date

  • January 1, 1990